Effects of Cell Grafting on Coronary Remodeling After Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Effects of Cell Grafting on Coronary Remodeling After Myocardial Infarction
BACKGROUND With recent advances in therapeutic applications of stem cells, cell engraftment has become a promising therapy for replacing injured myocardium after infarction. The survival and function of injected cells, however, will depend on the efficient vascularization of the new tissue. Here we describe the arteriogenic remodeling of the coronary vessels that supports vascularization of eng...
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OBJECTIVES We compared biological repair after acute myocardial infarction (AMI) with selected porcine progenitor cell populations. BACKGROUND Cell types and mechanisms responsible for myocardial repair after AMI remain uncertain. METHODS In a blinded, randomized study, we infused autologous late-outgrowth endothelial progenitor cells (EPC) (n = 10, 34 +/- 22 x 10(6) CD29-31-positive, capab...
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BACKGROUND Targeted delivery of mesenchymal precursor cells (MPCs) can modify left ventricular (LV) cellular and extracellular remodeling after myocardial infarction (MI). However, whether and to what degree LV remodeling may be affected by MPC injection post-MI, and whether these effects are concentration-dependent, remain unknown. METHODS AND RESULTS Allogeneic MPCs were expanded from sheep...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2013
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.113.000202